6/17/2023 0 Comments Taurine deficiency![]() Maeda T, Gupta MP, Stewart AF (2002) TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters. Kook SH, Choi KC, Son YO, Lee KY, Hwang IH, Lee HJ, Chung WT, Lee CB, Park JS, Lee JC (2008) Involvement of p38 MAPK-mediated signaling in the calpeptin-mediated suppression of myogenic differentiation and fusion in C2C12 cells. Kaisaki PJ, Jerkins AA, Goodspeed DC, Steele RD (1995) Cloning and characterization of rat cysteine sulfinic acid decarboxylase. Jacobsen JG, Smith LH (1968) Biochemistry and physiology of taurine and taurine derivatives. Iwata H, Obara T, Kim BK, Baba A (1986) Regulation of taurine transport in rat skeletal muscle. Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, Schaffer SW, Fujio Y, Azuma J (2008) Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. Hosokawa Y, Matsumoto A, Oka J, Itakura H, Yamaguchi K (1990) Isolation and characterization of a cDNA for rat liver cysteine dioxygenase. Heller-Stilb B, van Roeyen C, Rascher K, Hartwig HG, Huth A, Seeliger MW, Warskulat U, Haussinger D (2002) Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. Gossett LA, Kelvin DJ, Sternberg EA, Olson EN (1989) A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. ![]() ![]() Acta Neurol Scand 81:1–7ĭe Arcangelis V, Coletti D, Canato M, Molinaro M, Adamo S, Reggiani C, Naro F (2005) Hypertrophy and transcriptional regulation induced in myogenic cell line L6-C5 by an increase of extracellular calcium. J Perinat Med 30:281–286Īiraksinen EM, Paljarvi L, Partanen J, Collan Y, Laakso R, Pentikainen T (1990) Taurine in normal and diseased human skeletal muscle. This process is experimental and the keywords may be updated as the learning algorithm improves.Īerts L, Van Assche FA (2002) Taurine and taurine-deficiency in the perinatal period. These keywords were added by machine and not by the authors. The present study suggested that exogenous taurine might play a key role on the mature differentiation/growth of the skeletal muscle during development period through Ca 2+ signaling pathway, and therefore, taurine would contribute the muscle recovery after damages. In the present study, we confirmed, in cultured mouse differentiable myoblast, taurine treatment significantly enhanced the differentiation to myotube in a dose-dependent manner, while these effects were abrogated by inhibitions of taurine transport and Ca 2+ signaling pathway. In general cell culture condition, taurine contained in the culture medium is absent or few, and therefore, most of cultured cells are in taurine-deficient condition. In fetal and neonatal periods, taurine must be an essential amino acid due to no biosynthesis capacity, and therefore, taurine should be endogenously supplied through placenta and maternal milk. The previous studies in the taurine transporter knockout mice showed that deficiency of taurine content in the skeletal muscle caused incomplete muscular developments, morphological abnormalities, and exercise abilities. Taurine abundantly contained in the skeletal muscle has been considered as one of essential factors for the differentiation and growth of skeletal muscles.
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